863918-78-9
Chemical Structure
Methoxy-X04
- CAS No.: 863918-78-9
- Formula:C23H20O3
- Molecular Weight:344.40
IUPAC Name: 4,4'-((1E,1'E)-(2-methoxy-1,4-phenylene)bis(ethene-2,1-diyl))diphenol
InChIKey: FGYNZFHVGOFCMD-KHVHPYDTSA-N
SMILES: COC1=CC(/C=C/C2=CC=C(O)C=C2)=CC=C1/C=C/C3=CC=C(O)C=C3
Biological Activity: Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM). Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Methoxy-X04 | 98.65% | Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM). Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity. | ||||||||||||||||||||
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Methoxy-X04 (Standard) | ≥98% | Methoxy-X04 (Standard) is the analytical standard of Methoxy-X04 (HY-103240). This product is intended for research and analytical applications. Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM). Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity. | ||||||||||||||||||||
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Methoxy-X04 (solution) | Methoxy-X04 (solution) is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM). Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity. Solvent and concentration: DMSO: 5 mg/mL |
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Similarity Score 0.81
HY-103470K114 -
Similarity Score 0.67
HY-W4563594,4'-((1E,1'E)-(2,5-Dimethoxy-1,4-phenylene)bis(ethene-2,1-diyl))dibenzoic acid -
Similarity Score 0.67
![4-[2-[4-[2-(4-carboxyphenyl)ethenyl]-2,5-dimethoxyphenyl]ethenyl]benzoic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586992.gif)
HY-W5869924-[2-[4-[2-(4-carboxyphenyl)ethenyl]-2,5-dimethoxyphenyl]ethenyl]benzoic acid -
Similarity Score 0.64
HY-176970Antimicrobial agent-45 -
Similarity Score 0.64
HY-N3059RPinostilbene (Standard) -
Similarity Score 0.62
HY-D0728Fluorescent Brightener ER-III -
Similarity Score 0.61
HY-125962X-34 -
Similarity Score 0.61
HY-N0828RPterostilbene (Standard) -
Similarity Score 0.61
![1,4-Bis[2-(4-pyridyl)ethenyl]benzene Chemical Structure](//file.medchemexpress.com/product_pic/hy-w075129.gif)
HY-W0751291,4-Bis[2-(4-pyridyl)ethenyl]benzene -
Explore the MedChemAI to find more analogs
![4-[2-[4-[2-(4-carboxyphenyl)ethenyl]-2,5-dimethoxyphenyl]ethenyl]benzoic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586992.gif)
![1,4-Bis[2-(4-pyridyl)ethenyl]benzene Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w075129.gif)
References
- [1]. Bisht K, et al. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques. J Vis Exp. 2016 Jun 1;(112):54060. [Content Brief]
- [2]. Klunk WE, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep;61(9):797-805. [Content Brief]
