86487-64-1
Chemical Structure
Setoperone
- CAS No.: 86487-64-1
- Formula:C21H24FN3O2S
- Molecular Weight:401.50
IUPAC Name: 6-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one
InChIKey: RBGAHDDQSRBDOG-UHFFFAOYSA-N
SMILES: O=C1C(CCN2CCC(CC2)C(C3=CC=C(C=C3)F)=O)=C(N=C4N1CCS4)C
Biological Activity: Setoperone is an orally active and potent 5-HT₂ receptor antagonist and a moderate dopamine D₂ receptor blocker. Setoperone dissociates from the receptors relatively quickly, but it is easily "captured" by serotonin receptors in the body, resulting in persistent receptor inhibition even after elution. Setoperone can be used to study the negative symptoms of type II schizophrenia and associated mood disorders[1][2].
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Setoperone | Setoperone is an orally active and potent 5-HT₂ receptor antagonist and a moderate dopamine D₂ receptor blocker. Setoperone dissociates from the receptors relatively quickly, but it is easily "captured" by serotonin receptors in the body, resulting in persistent receptor inhibition even after elution. Setoperone can be used to study the negative symptoms of type II schizophrenia and associated mood disorders. | |||||||||||||||||||||
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- [1]. Ceulemans DL, et al. Effect of serotonin antagonism in schizophrenia: a pilot study with setoperone. Psychopharmacology (Berl). 1985;85(3):329-32.
- [2]. Leysen JE, et al. Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists: ritanserin and setoperone. Psychopharmacology (Berl). 1986;88(4):434-44. [Content Brief]
Keywords
