865488-53-5
865488-53-5
Chemical Structure
DM-NOFD
- CAS No.: 865488-53-5
- Formula:C13H15NO5
- Molecular Weight:265.26
IUPAC Name: methyl (2-methoxy-2-oxoacetyl)-D-phenylalaninate
InChIKey: CAUUPQLNYYFMOQ-SNVBAGLBSA-N
SMILES: COC(C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)=O
Biological Activity: DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DM-NOFD | 99.81% | DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.84
HY-W072177Methyl acetyl-D-phenylalaninate -
Similarity Score 0.84
HY-W101366AC-PHE-OME -
Similarity Score 0.81
HY-178915ITA-5 -
Similarity Score 0.78
HY-30090N-Boc-L-phenylalanine methyl ester -
Similarity Score 0.78
HY-W039758Methyl (tert-butoxycarbonyl)-D-phenylalaninate -
Similarity Score 0.77
HY-W142120β-Asp-Phe methyl ester -
Similarity Score 0.77
HY-B0361RAspartame (Standard) -
Similarity Score 0.73
HY-150012RN-Lactoyl-phenylalanine (Standard) -
Similarity Score 0.72
HY-201283A((R)-3-Hydroxybutanoyl)-L-phenylalanine lithium -
Explore the MedChemAI to find more analogs
References
- [1]. Luczak MW, Krawic C, Zhitkovich A. NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. Cell Cycle. 2021 Sep;20(18):1812-1827. [Content Brief]
- [2]. Corner TP, et al. Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chem Sci. 2023 Oct 27;14(43):12098-12120. [Content Brief]
