DM-NOFD
Based on 1 Customer Validation
DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF).
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 865488-53-5
- Formula: C13H15NO5
- Molecular Weight:265.26
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
Chemical Information
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CAS No. 865488-53-5
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Appearance Oil
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Molecular Weight 265.26
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Formula C13H15NO5
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Color Colorless to light yellow
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SMILES
COC(C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Luczak MW, Krawic C, Zhitkovich A. NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. Cell Cycle. 2021 Sep;20(18):1812-1827. [Content Brief]
[2]. Corner TP, et al. Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chem Sci. 2023 Oct 27;14(43):12098-12120. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)