867365-76-2
Chemical Structure
Depulfavirine
Synonym(s): Ro-0335
- No. CAS: 867365-76-2
- Formula:C21H13BrCl2FN3O4S
- Molecular Weight:573.22
IUPAC Name: 2-(4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl)-N-(2-chloro-4-sulfamoylphenyl)acetamide
InChIKey: SBUUICLVCQQMFP-UHFFFAOYSA-N
SMILES: ClC1=CC(OC2=C(F)C(CC(NC3=CC=C(S(=O)(N)=O)C=C3Cl)=O)=CC=C2Br)=CC(C#N)=C1
Biological Activity: RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1].
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Depulfavirine | 99.48% | RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates. | ||||||||||||||||||||
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Keywords
