867365-76-2
867365-76-2
Chemical Structure
Depulfavirine
Synonym(s): Ro-0335
- CAS No.: 867365-76-2
- Formula:C21H13BrCl2FN3O4S
- Molecular Weight:573.22
IUPAC Name: 2-(4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl)-N-(2-chloro-4-sulfamoylphenyl)acetamide
InChIKey: SBUUICLVCQQMFP-UHFFFAOYSA-N
SMILES: ClC1=CC(OC2=C(F)C(CC(NC3=CC=C(S(=O)(N)=O)C=C3Cl)=O)=CC=C2Br)=CC(C#N)=C1
Biological Activity: RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Depulfavirine | 99.48% | RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.84
HY-109056RElsulfavirine (Standard) -
Similarity Score 0.84
HY-109056AElsulfavirine sodium -
Similarity Score 0.57
HY-116732GW-678248 -
Similarity Score 0.52
HY-160645P2X4 antagonist-1 -
Similarity Score 0.51
HY-160677P2X4 antagonist-2 -
Similarity Score 0.51
HY-149775Urease-IN-10 -
Similarity Score 0.50
HY-130605BAY-1797 -
Similarity Score 0.49
HY-153971URAT1 inhibitor 8 -
Similarity Score 0.49
HY-176195P2X4-IN-1 -
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