870087-37-9
870087-37-9
Chemical Structure
Apilimod hydrochloride
Synonym(s): STA 5326 hydrochloride; LAM-002A free base hydrochloride; AIT-101 hydrochloride
- CAS. Nr.: 870087-37-9
- Formula:C23H28Cl2N6O2
- Molecular Weight:491.41
InChIKey: PJPZEUCDSIGFOW-OKUPSQOASA-N
SMILES: CC1=CC=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=CC=CC=N4)=N2)=C1.Cl.Cl
Biological Activity: Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19.
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Apilimod hydrochloride | Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19. | |||||||||||||||||||||
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