882278-66-2
882278-66-2
Chemical Structure
JFD00950
- CAS No.: 882278-66-2
- Formula:C16H6Cl4O3
- Molecular Weight:388.03
InChIKey: ZFBYNRLQXMCZPT-UHFFFAOYSA-N
SMILES: O=C1C(Cl)=C(C(C2=C1C=CC=C2)=O)OC3=CC(Cl)=C(C=C3Cl)Cl
Biological Activity: JFD00950 is a human FEN1 inhibitor with an IC50 of 5.5 μM. JFD00950 binds directly to FEN1, alters the secondary structure of this protein, and competitively inhibits its flap cleavage activity by interfering with substrate binding. JFD00950 selectively reduces the viability of cancer cells. JFD00950 can be used in the research of colon cancer and breast cancer[1].
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JFD00950 | JFD00950 is a human FEN1 inhibitor with an IC50 of 5.5 μM. JFD00950 binds directly to FEN1, alters the secondary structure of this protein, and competitively inhibits its flap cleavage activity by interfering with substrate binding. JFD00950 selectively reduces the viability of cancer cells. JFD00950 can be used in the research of colon cancer and breast cancer. | |||||||||||||||||||||
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References
Keywords
