892772-75-7
892772-75-7
Chemical Structure
EAI001
- CAS No.: 892772-75-7
- Formula:C19H15N3O2S
- Molecular Weight:349.41
IUPAC Name: 2-(1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide
InChIKey: PWRVRDCBFYLYFU-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=CC=C1)N2C(C(C=CC=C3)=C3C2)=O)NC4=NC=CS4
Biological Activity: EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer[1][2].
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EAI001 | 99.93% | EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer. | ||||||||||||||||||||
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EAI001 (Standard) | ≥98% | EAI001 (Standard) is the analytical standard of EAI001 (HY-100214). This product is intended for research and analytical applications. EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.74
HY-100213EAI045 -
Similarity Score 0.68
HY-135914JBJ-02-112-05 -
Similarity Score 0.63
HY-151048JBJ-07-149 -
Similarity Score 0.60
HY-123984LTβR-IN-1 -
Similarity Score 0.53
HY-135805JBJ-04-125-02 -
Similarity Score 0.53
HY-135805A(Rac)-JBJ-04-125-02 -
Similarity Score 0.53
HY-147183JBJ-09-063 -
Similarity Score 0.51
HY-126025α-Phthalimidopropiophenone -
Similarity Score 0.51
HY-148132GSK-3β inhibitor 11 -
Explore the MedChemAI to find more analogs
References
- [1]. Maity S, et, al. Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance. Pharmacol Rep. 2020 Aug;72(4):799-813. [Content Brief]
- [2]. Tinivella A, et, al. Investigating the selectivity of allosteric inhibitors for mutant t790m egfr over wild type using molecular dynamics and binding free energy calculations. 2018 Dec 4;3(12):16556-62.
