893555-90-3
893555-90-3
Chemical Structure
Revamilast
Synonym(s): GRC 4039
- CAS No.: 893555-90-3
- Formula:C18H9Cl2F2N3O4
- Molecular Weight:440.18
IUPAC Name: 3,5-dichloro-4-(6-(difluoromethoxy)benzofuro[3,2-c]pyridine-9-carboxamido)pyridine 1-oxide
InChIKey: IXQHNBONEVULTL-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=C3C=CN=C2)C(O3)=C(OC(F)F)C=C1)NC4=C(Cl)C=[N+]([O-])C=C4Cl
Biological Activity: Revamilast (GRC 4039) is an orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 3 nM. Revamilast inhibits the production of TNF-α. It can be used for research on rheumatoid arthritis, plaque psoriasis, asthma, and other inflammatory diseases[1].
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Revamilast | Revamilast (GRC 4039) is an orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 3 nM. Revamilast inhibits the production of TNF-α. It can be used for research on rheumatoid arthritis, plaque psoriasis, asthma, and other inflammatory diseases. | |||||||||||||||||||||
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