90719-30-5
Chemical Structure
Locostatin
Synonym(s): UIC-1005
- CAS No.: 90719-30-5
- Formula:C14H15NO3
- Molecular Weight:245.27
IUPAC Name: (S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one
InChIKey: UTZAFVPPWUIPBH-QSLRECBCSA-N
SMILES: O=C1OC[C@H](CC2=CC=CC=C2)N1C(/C=C/C)=O
Biological Activity: Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin can be used to synthesize chemical probes toward PEBP-proteins. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Locostatin | 99.88% | Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin can be used to synthesize chemical probes toward PEBP-proteins. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice . | ||||||||||||||||||||
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Similarity Score 1.00
HY-W013411(E/Z)-Locostatin -
Similarity Score 0.77
HY-W741021(S)-4-Benzyl-3-propionyloxazolidin-2-done3 -
Similarity Score 0.77
HY-W750774(R)-4-Benzyl-3-propionyloxazolidin-2-one-d3 -
Similarity Score 0.75
HY-42520(S)-4-Benzyl-3-(5-bromopentanoyl)oxazolidin-2-one -
Similarity Score 0.62
HY-137407N-Phenylacetyl-L-homoserine lactone -
Similarity Score 0.60
HY-N13432Cyclo(Ala-Phe) -
Similarity Score 0.59
HY-W011750Z-Pyr-OH -
Similarity Score 0.59
HY-N12158Pipermethystine -
Similarity Score 0.59
HY-170736Methamphetamine ethyl carbamate -
Explore the MedChemAI to find more analogs
References
- [1]. Beshir AB, et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58. [Content Brief]
- [2]. Mc Henry KT, et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11. [Content Brief]
- [3]. Lin X, et al. Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. Exp Ther Med. 2018 Oct;16(4):2992-2998. [Content Brief]
