91901-11-0
Chemical Structure
AGMO-IN-1
- CAS No.: 91901-11-0
- Formula:C10H17N5O
- Molecular Weight:223.27
InChIKey: AJYOESSYMNNERE-UHFFFAOYSA-N
SMILES: O=C1N=C(N(C)C)NC2=C1NC(C)C(C)N2
Biological Activity: AGMO-IN-1 is an alkylglycerol monooxygenase (AGMO) inhibitor. AGMO-IN-1 competitively binds with BH4 at the cofactor-binding site of BH4-dependent AGMO, inhibiting AGMO activity (rat IC50 = 26-100 µM); AGMO-IN-1 shows weaker inhibitory activity against PAH and NOS than against AGMO. AGMO-IN-1 inhibits preadipocyte differentiation, reduces lipid droplet accumulation in adipocytes and hepatocytes, blocks IL-4-induced M2-like polarization of macrophages, and slows cell cycle progression during the mitotic clonal expansion phase, making it useful for research related to nonalcoholic hepatic steatosis[1].
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AGMO-IN-1 | AGMO-IN-1 is an alkylglycerol monooxygenase (AGMO) inhibitor. AGMO-IN-1 competitively binds with BH4 at the cofactor-binding site of BH4-dependent AGMO, inhibiting AGMO activity (rat IC50 = 26-100 µM); AGMO-IN-1 shows weaker inhibitory activity against PAH and NOS than against AGMO. AGMO-IN-1 inhibits preadipocyte differentiation, reduces lipid droplet accumulation in adipocytes and hepatocytes, blocks IL-4-induced M2-like polarization of macrophages, and slows cell cycle progression during the mitotic clonal expansion phase, making it useful for research related to nonalcoholic hepatic steatosis. | |||||||||||||||||||||
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