921099-13-0
921099-13-0
Chemical Structure
TM-1
- CAS No.: 921099-13-0
- Formula:C26H32N2O6
- Molecular Weight:468.54
IUPAC Name: 3-(3,4-dimethoxyphenyl)-7-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethoxy)-4-methyl-2H-chromen-2-one
InChIKey: FJPOSFVCWXTUDP-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(OC)C(OC)=C2)=C(C)C3=CC=C(OCCN4CCN(CCO)CC4)C=C3O1
Biological Activity: TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TM-1 | 99.05% | TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation. | ||||||||||||||||||||
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