921099-13-0
921099-13-0
Chemical Structure
TM-1
- CAS. Nr.: 921099-13-0
- Formula:C26H32N2O6
- Molecular Weight:468.54
IUPAC Name: 3-(3,4-dimethoxyphenyl)-7-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethoxy)-4-methyl-2H-chromen-2-one
InChIKey: FJPOSFVCWXTUDP-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(OC)C(OC)=C2)=C(C)C3=CC=C(OCCN4CCN(CCO)CC4)C=C3O1
Biological Activity: TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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TM-1 | 99.05% | TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-19225Ensaculin -
Similarity Score 0.58
HY-124777NPD4456 -
Similarity Score 0.58
HY-19225AEnsaculin free base -
Similarity Score 0.55
HY-177281IL-6-IN-3 -
Similarity Score 0.54
HY-128859EMT inhibitor-2 -
Similarity Score 0.54
HY-N15412Cabreuvin -
Similarity Score 0.53
HY-153475IRE1α kinase-IN-9 -
Similarity Score 0.52
HY-173450ZL0516 -
Similarity Score 0.52
HY-153474IRE1α kinase-IN-8 -
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