ZL0516
ZL0516 is a potent, selective, and orally active BRD4 BD1 inhibitor. ZL0516 suppresses inflammatory bowel disease (IBD) by inhibiting BRD4/NF-κB signaling.
For research use only. We do not sell to patients.
- CAS No.: 2230496-93-0
- Formula: C27H34N2O6
- Molecular Weight:482.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2230496-93-0
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Molecular Weight 482.57
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Formula C27H34N2O6
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SMILES
COC1=C2C(OC(C3=CC(C)=C(OC[C@H](O)CN4CCN(C)CC4)C(C)=C3)=CC2=O)=CC(OC)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ma Z, et al. Orally Bioavailable BRD4 BD1 Inhibitor ZL0516 Effectively Suppresses Colonic Inflammation in Animal Models of Inflammatory Bowel Disease. ACS Pharmacol Transl Sci. 2025 Apr 1;8(4):1152-1167. [Content Brief]
[2]. Lu J, et al. Rational Design of the First Dual Agonist at Trace Amine-Associated Receptor 1 and 5-HT2C Receptors Based on Binding Pocket Similarity for the Treatment of Schizophrenia and Alzheimer's Disease-Related Psychosis. J Med Chem. 2025 Apr 10;68(7):7082-7105. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZL0516 Related Classifications
HY-173450 Related Classifications
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