923262-96-8
923262-96-8
Chemical Structure
SAR407899 hydrochloride
- CAS No.: 923262-96-8
- Formula:C14H17ClN2O2
- Molecular Weight:280.75
IUPAC Name: 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride
InChIKey: KMNVOGVCCZNVNU-UHFFFAOYSA-N
SMILES: O=C(NC=C1)C(C1=C2)=CC=C2OC3CCNCC3.[H]Cl
Biological Activity: SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.
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SAR407899 hydrochloride | 99.14% | SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-15687ASAR407899 -
Similarity Score 0.66
HY-W098166Methyl 4-(piperidin-4-yloxy)benzoate hydrochloride -
Similarity Score 0.61
HY-146502PARP10/15-IN-3 -
Similarity Score 0.59
HY-143338ART-IN-1 -
Similarity Score 0.58
HY-161413Antibacterial agent 204 -
Similarity Score 0.58
HY-19172349U85 hydrochloride -
Similarity Score 0.57
HY-123138LY206130 free base -
Similarity Score 0.57
HY-14477UPF-1035 -
Similarity Score 0.57
![4-[(Trans-4-aminocyclohexyl)oxy]-2-chloro-Benzonitrile hydrochloride Chemical Structure](//file.medchemexpress.com/product_pic/hy-w145437.gif)
HY-W1454374-[(Trans-4-aminocyclohexyl)oxy]-2-chloro-Benzonitrile hydrochloride -
Explore the MedChemAI to find more analogs
![4-[(Trans-4-aminocyclohexyl)oxy]-2-chloro-Benzonitrile hydrochloride Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w145437.gif)
