928046-68-8
Chemical Structure
CTDP-32476
- CAS No.: 928046-68-8
- Formula:C16H25Cl2N
- Molecular Weight:302.28
IUPAC Name: (R)-2-((R)-1-(4-chlorophenyl)-3-methylbutyl)piperidine hydrochloride
InChIKey: OTVLYTHPUXHDAQ-QNBGGDODSA-N
SMILES: [C@@H](CC(C)C)(C1=CC=C(Cl)C=C1)[C@]2(CCCCN2)[H].Cl
Biological Activity: CTDP-32476 is a dopamine transporter (DAT) inhibitor with a Ki value of 12 nM for human DAT, and exhibits moderate affinity for norepinephrine transporter (NET). CTDP-32476 blocks DAT to increase extracellular dopamine levels, induces motor enhancement and brain stimulation reward effects in rats, inhibits self-administration behavior and cue-induced relapse behavior, and shows no reinforcing activity with low addiction potential. CTDP-32476 can be used in studies related to addiction to tropane alkaloid psychostimulants[1].
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CTDP-32476 | CTDP-32476 is a dopamine transporter (DAT) inhibitor with a Ki value of 12 nM for human DAT, and exhibits moderate affinity for norepinephrine transporter (NET). CTDP-32476 blocks DAT to increase extracellular dopamine levels, induces motor enhancement and brain stimulation reward effects in rats, inhibits self-administration behavior and cue-induced relapse behavior, and shows no reinforcing activity with low addiction potential. CTDP-32476 can be used in studies related to addiction to tropane alkaloid psychostimulants. | |||||||||||||||||||||
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Keywords
