929256-79-1
Chemical Structure
VJ115
- CAS No.: 929256-79-1
- Formula:C23H24N2O
- Molecular Weight:344.46
IUPAC Name: (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)quinuclidin-3-ol
InChIKey: QSSJQRUIQVSAQK-HMAPJEAMSA-N
SMILES: C(\C=1C=2C(N(CC3=CC=CC=C3)C1)=CC=CC2)=C/4\N5CCC(C4O)CC5
Biological Activity: VJ115 is a potent ENOX1 inhibitor with an EC50 of 50 μM. By inhibiting ENOX1, VJ115 elevates NADH, which in turn downregulates the phosphorylation of p70S6K1/S6, alters the expression of c-Jun and cytoskeletal proteins, induces endothelial cells to lose polarization and migration ability, and increases caspase-3-dependent apoptosis under radiation. VJ115 can be used in studies related to solid tumors[1][2].
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VJ115 | VJ115 is a potent ENOX1 inhibitor with an EC50 of 50 μM. By inhibiting ENOX1, VJ115 elevates NADH, which in turn downregulates the phosphorylation of p70S6K1/S6, alters the expression of c-Jun and cytoskeletal proteins, induces endothelial cells to lose polarization and migration ability, and increases caspase-3-dependent apoptosis under radiation. VJ115 can be used in studies related to solid tumors. | |||||||||||||||||||||
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- [1]. Venkateswaran A, et al. The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Investigational new drugs. 2013 Jun;31(3):535-44.
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[2]. Geng L, et al. Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature. FASEB J. 2009 Sep;23(9):2986-95.
Keywords
