93117-08-9
93117-08-9
Chemical Structure
5-AIQ
Synonym(s): 5-Aminoisoquinolin-1-one
- CAS No.: 93117-08-9
- Formula:C9H8N2O
- Molecular Weight:160.18
IUPAC Name: 5-aminoisoquinolin-1(2H)-one
InChIKey: SVASVGVAQIVSEZ-UHFFFAOYSA-N
SMILES: O=C1NC=CC2=C1C=CC=C2N
Biological Activity: 5-AIQ (5-Aminoisoquinolin-1-one) is a PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver[1][2].
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5-AIQ | 99.75% | 5-AIQ (5-Aminoisoquinolin-1-one) is a PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver. | ||||||||||||||||||||
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5-AIQ (Standard) | ≥98% | 5-AIQ (5-Aminoisoquinolin-1-one) is a PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-W006566A5-AIQ hydrochloride -
Similarity Score 0.89
HY-W015422R1,5-Isoquinolinediol (Standard) -
Similarity Score 0.85
HY-W0020141(2H)-Isoquinolinone -
Similarity Score 0.81
HY-W110138Chloroxoquinoline -
Similarity Score 0.80
HY-W0125661,5-Naphthalenediamine -
Similarity Score 0.80
HY-W0188004(3H)-Quinazolinone -
Similarity Score 0.79
HY-236368-Chloroisoquinolin-3(2H)-one -
Similarity Score 0.78
HY-W0010235-Amino-8-hydroxyquinoline -
Similarity Score 0.78
HY-15922Luminol -
Explore the MedChemAI to find more analogs
References
- [1]. Vinod KR, Chandra S, Sharma SK. Evaluation of 5-aminoisoquinoline (5-AIQ), a novel PARP-1 inhibitor for genotoxicity potential in vitro and in vivo. Toxicol Mech Methods. 2010 Feb;20(2):90-5. [Content Brief]
- [2]. Mota-Filipe H, et al. The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat. Med Sci Monit. 2002 Nov;8(11):BR444-53. [Content Brief]
