932986-18-0
Chemical Structure
Azoramide
- CAS No.: 932986-18-0
- Formula:C15H17ClN2OS
- Molecular Weight:308.83
IUPAC Name: N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyramide
InChIKey: VYBFWKKCWTXCQX-UHFFFAOYSA-N
SMILES: CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O
Biological Activity: Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Azoramide | 99.57% | Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity. | ||||||||||||||||||||
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- [1]. Fu S, et, al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015 Jun 17;7(292):292ra98. [Content Brief]
- [2]. Ke M, et, al. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11(2):130. [Content Brief]
Keywords
