936233-18-0
936233-18-0
Chemical Structure
CML-d4
- CAS No.: 936233-18-0
- Formula:C8H12D4N2O4
- Molecular Weight:208.25
IUPAC Name: N6-(carboxymethyl)-L-lysine-4,4,5,5-d4
InChIKey: NUXSIDPKKIEIMI-WCEGGVOZSA-N
SMILES: N[C@@H](CC([2H])([2H])C([2H])([2H])CNCC(O)=O)C(O)=O
Biological Activity: CML-d4 is the deuterium labeled Fmoc-L-Lys (Boc)-OH[1].
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CML-d4 | 99.76% | CML-d4 is the deuterium labeled Fmoc-L-Lys (Boc)-OH. | ||||||||||||||||||||
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CML-d3 | 99.0% | CML-d3 is the deuterium labeled CML. | ||||||||||||||||||||
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Nε-(Carboxymethyl)-L-lysine | 95.0% | Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties. | ||||||||||||||||||||
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References
