936349-47-2
Chemical Structure
AM103 free acid
- CAS No.: 936349-47-2
- Formula:C36H39N3O4S
- Molecular Weight:609.78
IUPAC Name: 3-(3-(tert-butylthio)-1-(4-(6-methoxypyridin-3-yl)benzyl)-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
InChIKey: DGCSBHYGDCRAOB-UHFFFAOYSA-N
SMILES: O=C(C(C)(CC1=C(C2=C(N1CC3=CC=C(C4=CC=C(OC)N=C4)C=C3)C=CC(OCC5=NC=CC=C5)=C2)SC(C)(C)C)C)O
Biological Activity:
AM103 (free acid) is a selective FLAP inhibitor that can block the first step of the LT pathway, which is 5-LO activation. AM103 (free acid) can inhibit the production of LTB4 and cysteinyl leukotrienes (CysLT). AM103 (free acid) has anti-inflammatory activity in a mouse model of chronic lung inflammation and can extend the survival time of mice injected with platelet-activating factor. AM103 (free acid) can be used for research on respiratory diseases such as asthma[1].
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AM103 free acid | AM103 (free acid) is a selective FLAP inhibitor that can block the first step of the LT pathway, which is 5-LO activation. AM103 (free acid) can inhibit the production of LTB4 and cysteinyl leukotrienes (CysLT). AM103 (free acid) has anti-inflammatory activity in a mouse model of chronic lung inflammation and can extend the survival time of mice injected with platelet-activating factor. AM103 (free acid) can be used for research on respiratory diseases such as asthma. |
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Keywords
