938069-71-7
Chemical Structure
CAY10526
- CAS No.: 938069-71-7
- Formula:C12H7BrO3S
- Molecular Weight:311.16
IUPAC Name: 4-(benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one
InChIKey: ICCDILPNCJIDAW-UHFFFAOYSA-N
SMILES: O=C1C(Br)=C(C(O1)O)C2=CC3=CC=CC=C3S2
Biological Activity: CAY10526 is an inhibitor of Y-box binding protein 1 (YB-1) and microsomal prostaglandin E2 synthase 1 (mPGES1). CAY10526 inhibits the production of PGE2 by suppressing YB-1 and mPGES1. CAY10526 induces cell apoptosis (apoptosis) and inhibits the JAK/STAT, TGF-β/Smad3 and PI3K/AKT signaling pathways. CAY10526 can be used in research related to melanoma, prostate cancer, esophageal adenocarcinoma, T-cell lymphoma, etc[1][2][3][4][5].
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CAY10526 | 99.12% | CAY10526 is an inhibitor of Y-box binding protein 1 (YB-1) and microsomal prostaglandin E2 synthase 1 (mPGES1). CAY10526 inhibits the production of PGE2 by suppressing YB-1 and mPGES1. CAY10526 induces cell apoptosis (apoptosis) and inhibits the JAK/STAT, TGF-β/Smad3 and PI3K/AKT signaling pathways. CAY10526 can be used in research related to melanoma, prostate cancer, esophageal adenocarcinoma, T-cell lymphoma, etc. | ||||||||||||||||||||
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[1]. Kim SH, et al. Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression. Pigment Cell Melanoma Res. 2016 May;29(3):297-308.
[Content Brief] - [2]. Xu LW, et al. Expression and significance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer. Asian Pac J Cancer Prev. 2012;13(4):1639-1644. [Content Brief]
- [3]. Lin YM, et al. Microsomal Prostaglandin E Synthase-1 Plays a Critical Role in Long-term Motility Dysfunction after Bowel Obstruction. Sci Rep. 2018;8(1):8831. Published 2018 Jun 11. [Content Brief]
- [4]. Beales IL, et al. Microsomal prostaglandin E synthase-1 inhibition blocks proliferation and enhances apoptosis in oesophageal adenocarcinoma cells without affecting endothelial prostacyclin production. Int J Cancer. 2010;126(9):2247-2255. [Content Brief]
- [5]. Li Y, et al. Growth of T-cell lymphoma cells is inhibited by mPGES-1/PGE2 suppression via JAK/STAT, TGF-β/Smad3 and PI3K/AKT signal pathways. Transl Cancer Res. 2022;11(7):2175-2184. [Content Brief]
Keywords
