93906-48-0
Chemical Structure
MRS2693
- CAS No.: 93906-48-0
- Formula:C9H13IN2O12P2
- Molecular Weight:530.06
IUPAC Name: ((2R,3S,4R,5R)-3,4-dihydroxy-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl trihydrogen diphosphate
InChIKey: TTYCBCDSPQHLDE-UAKXSSHOSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O[C@H]1N2C(NC(C(I)=C2)=O)=O
Biological Activity: MRS2693 is a selective P2Y6 receptor agonist. MRS2693 exerts biological effects by activating the Gq-coupled P2Y6 receptor, the ERK1/2 pathway, and the P2RY6-PLCB3-CAMKK2-PRKAA1-ULK1 signaling cascade. MRS2693 attenuates TNFα-induced NF-κB activation, stabilizes XIAP via AKT-mediated phosphorylation, induces autophagy, and reactivates PRKAA1. MRS2693 can be used in research on diseases including skeletal muscle ischemia/reperfusion injury, TNFα-induced skeletal muscle apoptosis, chronic myelomonocytic leukemia, colorectal cancer, and dry eye disease[1][2][3][4].
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MRS2693 | MRS2693 is a selective P2Y6 receptor agonist. MRS2693 exerts biological effects by activating the Gq-coupled P2Y6 receptor, the ERK1/2 pathway, and the P2RY6-PLCB3-CAMKK2-PRKAA1-ULK1 signaling cascade. MRS2693 attenuates TNFα-induced NF-κB activation, stabilizes XIAP via AKT-mediated phosphorylation, induces autophagy, and reactivates PRKAA1. MRS2693 can be used in research on diseases including skeletal muscle ischemia/reperfusion injury, TNFα-induced skeletal muscle apoptosis, chronic myelomonocytic leukemia, colorectal cancer, and dry eye disease. | |||||||||||||||||||||
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References
- [1]. Mamedova LK, et al. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacological research. 2008;58(3-4):232-9. [Content Brief]
- [2]. Obba S, et al. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy. 2015;11(7):1114-29. [Content Brief]
- [3]. Placet M, et al. The G protein-coupled P2Y6 receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis[J]. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2018, 1864(5): 1539-1551.
- [4]. Fjærvoll KA, et al. Pyrimidinergic P2Y1-Like Nucleotide Receptors Are Functional in Rat Conjunctival Goblet Cells. Investigative ophthalmology & visual science. 2025 Jan 02;66(1):46. [Content Brief]
