943434-15-9
943434-15-9
Chemical Structure
UNC5452
- CAS No.: 943434-15-9
- Formula:C17H20N4O2S
- Molecular Weight:344.43
IUPAC Name: N-(2-(dimethylamino)ethyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide
InChIKey: RULRLUFVKXIRNZ-UHFFFAOYSA-N
SMILES: O=S(=O)(NCCN(C)C)C=1C=CC(=CC1)C=2C=CN=C3NC=CC32
Biological Activity: UNC5452 is a selective, ATP-competitive Nek1 kinase inhibitor with an IC50 of 7.1 μM. UNC5452 inhibits IKKβ kinase activity. UNC5452 can be used for research on polycystic kidney disease[1][2].
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UNC5452 | UNC5452 is a selective, ATP-competitive Nek1 kinase inhibitor with an IC50 of 7.1 μM. UNC5452 inhibits IKKβ kinase activity. UNC5452 can be used for research on polycystic kidney disease. | |||||||||||||||||||||
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References
- [1]. Baumann G, et al. Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros. Journal of medicinal chemistry. 2022 Jan 27;65(2):1265-1282.
- [2]. Wells CI, et al. In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases. MedChemComm. 2018 Jan 01;9(1):44-66.
