955157-23-0
Chemical Structure
IRC-083927
- CAS. Nr.: 955157-23-0
- Formula:C22H19FN4O4S
- Molecular Weight:454.47
InChIKey: OTONMEUXEIQINP-UHFFFAOYSA-N
SMILES: O=S(N)(NC1=CC=C(C=C1F)OC2=CC=C(C3=CN=C(COC4=CC=CC=C4)N3)C=C2)=O
Biological Activity: IRC-083927 is an orally active tubulin inhibitor. IRC-083927 binds competitively to the colchicine-binding site on tubulin, inhibits tubulin polymerization, disrupts the microtubule cytoskeleton, and arrests the cell cycle at the G2-M phase. IRC-083927 can be used in research related to human cervical cancer, hormone-independent breast cancer, pancreatic cancer, prostate cancer, and small cell lung cancer[1][2].
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IRC-083927 | IRC-083927 is an orally active tubulin inhibitor. IRC-083927 binds competitively to the colchicine-binding site on tubulin, inhibits tubulin polymerization, disrupts the microtubule cytoskeleton, and arrests the cell cycle at the G2-M phase. IRC-083927 can be used in research related to human cervical cancer, hormone-independent breast cancer, pancreatic cancer, prostate cancer, and small cell lung cancer. | |||||||||||||||||||||
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- [1]. Liberatore AM, et al. IRC-083927 is a new tubulin binder that inhibits growth of human tumor cells resistant to standard tubulin-binding agents. Molecular cancer therapeutics. 2008 Aug;7(8):2426-34. [Content Brief]
- [2]. Chen SM, et al. New microtubule-inhibiting anticancer agents. Expert opinion on investigational drugs. 2010 Mar;19(3):329-43. [Content Brief]
Keywords
