956025-99-3
956025-99-3
Chemical Structure
3BrB-PP1
- CAS No.: 956025-99-3
- Formula:C16H18BrN5
- Molecular Weight:360.25
IUPAC Name: 3-(3-bromobenzyl)-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
InChIKey: FTICVONBLRGQJW-UHFFFAOYSA-N
SMILES: NC1=C2C(N(C(C)(C)C)N=C2CC3=CC=CC(Br)=C3)=NC=N1
Biological Activity: 3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3BrB-PP1 | 99.0% | 3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket). | ||||||||||||||||||||
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References
- [1]. Tay YD, et, al. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019 Feb 5;26(6):1654-1667.e7. [Content Brief]
- [2]. Mutavchiev DR, et, al. Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway. Curr Biol. 2016 Nov 7;26(21):2921-2928. [Content Brief]
