957486-82-7
Chemical Structure
Azido-PEG6-amine
- CAS No.: 957486-82-7
- Formula:C14H30N4O6
- Molecular Weight:350.41
IUPAC Name: 20-azido-3,6,9,12,15,18-hexaoxaicosan-1-amine
InChIKey: VCQSTKKJKNUQBI-UHFFFAOYSA-N
SMILES: NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Biological Activity: Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azido-PEG6-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Azido-PEG6-amine | 97.0% | Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Williams EGL, et al. Glycosylated Reversible Addition-Fragmentation Chain Transfer Polymers with Varying Polyethylene Glycol Linkers Produce Different Short Interfering RNA Uptake, Gene Silencing, and Toxicity Profiles. Biomacromolecules. 2017 Dec 11;18(12):4099-4112. [Content Brief]
- [2]. Philip Wilson Howard, et al. Pyrrolobenzodiazepines and conjugates thereof. WO2014140862A2.
Keywords
