959584-91-9
959584-91-9
Chemical Structure
PF 04254644
- No. CAS: 959584-91-9
- Formula:C20H17N7
- Molecular Weight:355.40
IUPAC Name: (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline
InChIKey: VQYHPUHKYSSEOB-ZDUSSCGKSA-N
SMILES: C[C@@H](C1=CC2=C(N=CC=C2)C=C1)C3=NN=C4N3N=C(C5=CN(C)N=C5)C=C4
Biological Activity: PF 04254644 is an orally active c-Met inhibitor. PF 04254644 inhibits mesenchymal transfer factor/hepatocyte growth factor receptor. PF 04254644 induces myocardial degeneration in rats. PF 04254644 may be used in research on cardiovascular disease and cancer[1][2].
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PF 04254644 | PF 04254644 is an orally active c-Met inhibitor. PF 04254644 inhibits mesenchymal transfer factor/hepatocyte growth factor receptor. PF 04254644 induces myocardial degeneration in rats. PF 04254644 may be used in research on cardiovascular disease and cancer. | |||||||||||||||||||||
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References
- [1]. Cui JJ, et al. Lessons from (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats. J Med Chem. 2013 Sep 12;56(17):6651-65. [Content Brief]
- [2]. Hu W, et al. A tyrosine kinase inhibitor-induced myocardial degeneration in rats through off-target phosphodiesterase inhibition. J Appl Toxicol. 2012 Dec;32(12):1008-20. [Content Brief]
