PF 04254644
PF 04254644 is an orally active c-Met inhibitor. PF 04254644 inhibits mesenchymal transfer factor/hepatocyte growth factor receptor. PF 04254644 induces myocardial degeneration in rats. PF 04254644 may be used in research on cardiovascular disease and cancer.
For research use only. We do not sell to patients.
- CAS No.: 959584-91-9
- Formula: C20H17N7
- Molecular Weight:355.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.006 μM
Compound: 8, PF-04254644
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Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA
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[PMID: 23944843] |
Chemical Information
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CAS No. 959584-91-9
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Molecular Weight 355.40
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Formula C20H17N7
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SMILES
C[C@@H](C1=CC2=C(N=CC=C2)C=C1)C3=NN=C4N3N=C(C5=CN(C)N=C5)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Cui JJ, et al. Lessons from (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats. J Med Chem. 2013 Sep 12;56(17):6651-65. [Content Brief]
[2]. Hu W, et al. A tyrosine kinase inhibitor-induced myocardial degeneration in rats through off-target phosphodiesterase inhibition. J Appl Toxicol. 2012 Dec;32(12):1008-20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF 04254644 Related Classifications
HY-14510 Related Classifications
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