97534-21-9
97534-21-9
Chemical Structure
Merbarone
Synonym(s): NSC 336628
- CAS No.: 97534-21-9
- Formula:C11H9N3O3S
- Molecular Weight:263.27
IUPAC Name: 4,6-dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide
InChIKey: JARCFMKMOFFIGZ-UHFFFAOYSA-N
SMILES: O=C(C(C(N1)=O)C(NC1=S)=O)NC2=CC=CC=C2
Biological Activity: Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent[1][2][4].
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Merbarone | 99.0% | Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent. | ||||||||||||||||||||
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Merbarone (Standard) | ≥98% | Merbarone (Standard) is the analytical standard of Merbarone. This product is intended for research and analytical applications. Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent. | ||||||||||||||||||||
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References
- [1]. Fortune JM, et, al. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. J Biol Chem. 1998 Jul 10;273(28):17643-50. [Content Brief]
- [2]. Brewer AD, et, al. 5-(N-phenylcarboxamido)-2-thiobarbituric acid (NSC 336628), a novel potential antitumor agent. Biochem Pharmacol. 1985 Jun 1;34(11):2047-50. [Content Brief]
- [4]. Chen M, et, al. Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26. Cancer Res. 1995 Apr 1;55(7):1509-16. [Content Brief]
Keywords
