99461-80-0
Chemical Structure
Neltenexine hydrochloride
- CAS No.: 99461-80-0
- Formula:C18H21Br2ClN2O2S
- Molecular Weight:524.70
IUPAC Name: N-(2,4-dibromo-6-((((1r,4r)-4-hydroxycyclohexyl)amino)methyl)phenyl)thiophene-2-carboxamide hydrochloride
InChIKey: ZVPWQPVEYLBIFG-SKKCDYJJSA-N
SMILES: N(C(=O)C1=CC=CS1)C2=C(CN[C@H]3CC[C@H](O)CC3)C=C(Br)C=C2Br.Cl
Biological Activity: Neltenexine hydrochloride is a mucolytic agent and an inhibitor of anion hypersecretion. Neltenexine hydrochloride acts on NKCC1, NBC1 and AE2 transporters located on the basolateral membrane of airway epithelial cells. Neltenexine hydrochloride reduces Cl-/HCO3- uptake by inhibiting NKCC1 and NBC1, activates AE2 to promote Cl- excretion, reduces β2-adrenergic agonist-induced anion hypersecretion without blocking CFTR channels, and maintains appropriate airway fluid levels. Neltenexine hydrochloride can be used in research related to chronic obstructive pulmonary disease and emphysema[1][2].
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Neltenexine hydrochloride | Neltenexine hydrochloride is a mucolytic agent and an inhibitor of anion hypersecretion. Neltenexine hydrochloride acts on NKCC1, NBC1 and AE2 transporters located on the basolateral membrane of airway epithelial cells. Neltenexine hydrochloride reduces Cl-/HCO3- uptake by inhibiting NKCC1 and NBC1, activates AE2 to promote Cl- excretion, reduces β2-adrenergic agonist-induced anion hypersecretion without blocking CFTR channels, and maintains appropriate airway fluid levels. Neltenexine hydrochloride can be used in research related to chronic obstructive pulmonary disease and emphysema. | |||||||||||||||||||||
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- [1]. Niisato N, et al. Action of neltenexine on anion secretion in human airway epithelia. Biochemical and biophysical research communications. 2007 May 18;356(4):1050-5. [Content Brief]
- [2]. Braga PC, et al. Neltenexine: morphological investigation of protection against elastase-induced emphysema in rats. Drugs under experimental and clinical research. 1995;21(2):51-7. [Content Brief]
Keywords
