Cbz-NH-PEG1-CH2CH2COOH

Cat. No.: HY-135926 Purity: 98.80%: FAQs
Data Sheet SDS COA Handling Instructions

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Cbz-NH-PEG1-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Cbz-NH-PEG1-CH2CH2COOH Chemical Structure

CAS No. : 1205751-19-4

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Biological Activity
Purity & Documentation
References
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Description

Cbz-NH-PEG1-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

267.28

Formula

C₁₃H₁₇NO₅

CAS No.

1205751-19-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCNC(OCC1=CC=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (374.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7414 mL	18.7070 mL	37.4139 mL
5 mM	0.7483 mL	3.7414 mL	7.4828 mL
10 mM	0.3741 mL	1.8707 mL	3.7414 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.80%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (243 KB) HNMR (127 KB) LCMS (246 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7414 mL	18.7070 mL	37.4139 mL	93.5349 mL
	5 mM	0.7483 mL	3.7414 mL	7.4828 mL	18.7070 mL
	10 mM	0.3741 mL	1.8707 mL	3.7414 mL	9.3535 mL
	15 mM	0.2494 mL	1.2471 mL	2.4943 mL	6.2357 mL
	20 mM	0.1871 mL	0.9353 mL	1.8707 mL	4.6767 mL
	25 mM	0.1497 mL	0.7483 mL	1.4966 mL	3.7414 mL
	30 mM	0.1247 mL	0.6236 mL	1.2471 mL	3.1178 mL
	40 mM	0.0935 mL	0.4677 mL	0.9353 mL	2.3384 mL
	50 mM	0.0748 mL	0.3741 mL	0.7483 mL	1.8707 mL
	60 mM	0.0624 mL	0.3118 mL	0.6236 mL	1.5589 mL
	80 mM	0.0468 mL	0.2338 mL	0.4677 mL	1.1692 mL
	100 mM	0.0374 mL	0.1871 mL	0.3741 mL	0.9353 mL