2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK-IN-13

CDK-IN-13 (compound 32E) is a potent and selective inhibitor of CDK12/cyclinK with an IC50 of 3 nM. CDK-IN-13 inhibits the growth of the HER2-positive breast cancer cell lines.

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CDK-IN-13

CDK-IN-13 Estructura química

No. CAS : 3041994-96-8

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CDK-IN-13 Related Antibodies

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Descripciòn

CDK-IN-13 (compound 32E) is a potent and selective inhibitor of CDK12/cyclinK with an IC50 of 3 nM. CDK-IN-13 inhibits the growth of the HER2-positive breast cancer cell lines[1].

Cellular Effect
Cell Line Type Value Description References
BT-474 GI50
0.01 μM
Compound: 32e
Antiproliferative activity against trastuzumab-sensitive HER2-positive human BT-474 cells by Cell Titer Glo assay
Antiproliferative activity against trastuzumab-sensitive HER2-positive human BT-474 cells by Cell Titer Glo assay
[PMID: 38061230]
JIMT-1 GI50
0.021 μM
Compound: 32e
Antiproliferative activity against trastuzumab-resistant HER2-positive human JIMT-1 cells by Cell Titer Glo assay
Antiproliferative activity against trastuzumab-resistant HER2-positive human JIMT-1 cells by Cell Titer Glo assay
[PMID: 38061230]
Peso molecular

449.51

Fòrmula

C23H27N7O3
No. CAS
SMILES

CCN1C=NC2=C(N=C(N=C21)N3CCOC[C@H]3CCO)NCC4=CN=C(C=C4)C5=COC=C5
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Room temperature in continental US; may vary elsewhere.
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CDK-IN-13 Related Classifications

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Keywords:

CDK-IN-133041994-96-8CDKCyclin dependent kinaseCDK12 inhibitorCyclinK degraderDinaciclibHER2-positive breast cancerInhibitorinhibitorinhibit

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Nombre del producto:
CDK-IN-13
Cat. No.:
HY-157297
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