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Cat. No.: HY-150946

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CDK9 ligand 2

CDK9 ligand 2 (compound CDK9 ligand 4) is a CDK9 ligand. CDK9 ligand 2 is used for the synthesis of PROTAC CDK9 degrader-14 (HY-133617).

For research use only. We do not sell to patients.

CAS No.: 1453836-45-7
Formula: C₂₁H₂₈N₆O
Molecular Weight:380.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK9 ligand 2 Chemical Structure

CAS No.: 1453836-45-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

CDK9 ligand 2 (compound CDK9 ligand 4) is a CDK9 ligand. CDK9 ligand 2 is used for the synthesis of PROTAC CDK9 degrader-14 (HY-133617)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	0.53 μM Compound: 4	Growth inhibition of human BT-549 cells assessed as cell viability measured after 4 days by WST8 assay Growth inhibition of human BT-549 cells assessed as cell viability measured after 4 days by WST8 assay	[PMID: 34538051]
MDA-MB-231	IC₅₀	3.01 μM Compound: 4	Growth inhibition of human MDA-MB-231 cells assessed as cell viability measured after 4 days by WST8 assay Growth inhibition of human MDA-MB-231 cells assessed as cell viability measured after 4 days by WST8 assay	[PMID: 34538051]
MDA-MB-468	IC₅₀	3.07 μM Compound: 4	Growth inhibition of human MDA-MB-468 cells assessed as cell viability measured after 4 days by WST8 assay Growth inhibition of human MDA-MB-468 cells assessed as cell viability measured after 4 days by WST8 assay	[PMID: 34538051]

In Vitro

CDK9 ligand 2 (compound CDK9 ligand 4) binds to the pocket of CDK9 (PDB: 3LQ5) via hydrogen bond formation with the Cys106 residue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1453836-45-7
Molecular Weight 380.49
Formula C₂₁H₂₈N₆O
SMILES

CC(C1=C2N=C(N=C(N2N=C1)NCC3=CC=CC=C3)OC4CCN(CC4)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wei D, et al. Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. Journal of medicinal chemistry. 2021 Oct 14;64(19):14822-14847. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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