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Art. -Nr.: HY-189684

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CETP-IN-5

CETP-IN-5 is a CETP inhibitor with an IC₅₀ of 75.54 nM. CETP-IN-5 is predicted by computer simulation to bind the central hydrophobic tunnel and restrict the lipid transfer pathway, thereby inhibiting neutral lipid transfer. CETP-IN-5 shows an inhibitory effect that increases with increasing N-alkyl ester chain length, with the longest-chain N-alkyl ester exhibiting the highest activity. CETP-IN-5 can be used for research on cardiovascular diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₇H₃₄F₃NO₂
Molecular Weight:461.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CETP-IN-5 Chemical Structure

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Lipid MetabolismOthers

Lipid Metabolism

CETP-IN-5 (compound 6d) (3 h) inhibits cholesteryl ester transfer in a fluorometric CETP inhibition assay using rabbit serum CETP, with an IC₅₀ of 75.54 nM^[1].

Others

CETP-IN-5 computational predictions show a log P of approximately 7.06, within the lipophilicity range of clinical CETP inhibitors, while not exceeding toxicological thresholds such as DILI/hERG, indicating an overall favorable safety profile^[1].
CETP-IN-5 was shown by 500 ns MD simulation to stably bind the CETP hydrophobic cavity (MM-PBSA binding free energy approximately -43.82 kcal/mol) and to interfere with cholesteryl ester/triglyceride transport by constricting the neutral lipid transfer tunnel (average widest channel radius 1.28 Å)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Lipid Droplets: Oil Red O/Sudan Dye Lipid Staining

Chemical Information

Molecular Weight 461.56
Formel C₂₇H₃₄F₃NO₂
SMILES

O=C(OCC)CCCCCN1C2=C(C)C=C(C)C=C2C(C3=CC=CC(C(F)(F)F)=C3)CCC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Nandi S, et al. Structure-guided design of N-alkylated benzazepine derivatives as potential CETP inhibitors. Bioorganic chemistry. 2026 Sep 15;182:110511.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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