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Cat. No.: HY-116197

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CGP44532

CGP44532 is a GABA_B receptor agonist with a pEC₅₀ (geometric mean of the half-maximal effective concentration) value of 5.63 μM.

For research use only. We do not sell to patients.

CAS No.: 133345-68-3
Formula: C₄H₁₂NO₃P
Molecular Weight:153.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

CGP44532 Chemical Structure

CAS No.: 133345-68-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CGP44532 is a GABA_B receptor agonist with a pEC₅₀ (geometric mean of the half-maximal effective concentration) value of 5.63 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	600 nM Compound: (R)-4	Agonist activity at human recombinant GABABreceptor expressed in CHO-K1 cells assessed as inhibition of intracellular calcium release by FLIPR Agonist activity at human recombinant GABABreceptor expressed in CHO-K1 cells assessed as inhibition of intracellular calcium release by FLIPR	[PMID: 18578471]
Oocyte	IC₅₀	5.4 μM Compound: R(+)-CGP-44533	Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method	[PMID: 17981464]

Chemical Information

CAS No. 133345-68-3
Molecular Weight 153.12
Formula C₄H₁₂NO₃P
SMILES

O=P(C)(C[C@H](O)CN)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Knight A R, et al. The pharmacology of adenylyl cyclase modulation by GABAB receptors in rat brain slices[J]. Neuropharmacology, 1996, 35(6): 703-712. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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