CGS 20625
Based on 1 Customer Validation
CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 enhances GABA in Xenopus laevis oocytes . CGS 20625 can be used for the research of pentylenetetrazol-induced seizures and anxiety.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 111205-55-1
- Formula: C18H19N3O2
- Molecular Weight:309.36
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 1.3 nM ([3H]-flunitrazepam binding to central benzodiazepine receptors)[1]
CGS 20625 (0.01-100 μM) significantly enhances GABA-induced chloride currents in Xenopus laevis oocytes expressing α1β2γ1 GABAA receptors[2].
CGS 20625 (0.01-100 μM) maximally enhances GABA in Xenopus laevis oocytes expressing α1β2γ2S GABAA receptors with an EC50 of 11.2 μM[2].
CGS 20625 (0.01-100 μM) enhances GABA in Xenopus laevis oocytes expressing α1β2 GABAA receptors, with an EC50[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 111205-55-1
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Appearance Solid
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Molecular Weight 309.36
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Formula C18H19N3O2
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Color Light yellow to yellow
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SMILES
O=C1C2=CNC(CCCCC3)=C3C2=NN1C4=CC=C(OC)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (161.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2325 mL | 16.1624 mL | 32.3248 mL | 80.8120 mL |
| 5 mM | 0.6465 mL | 3.2325 mL | 6.4650 mL | 16.1624 mL | |
| 10 mM | 0.3232 mL | 1.6162 mL | 3.2325 mL | 8.0812 mL | |
| 15 mM | 0.2155 mL | 1.0775 mL | 2.1550 mL | 5.3875 mL | |
| 20 mM | 0.1616 mL | 0.8081 mL | 1.6162 mL | 4.0406 mL | |
| 25 mM | 0.1293 mL | 0.6465 mL | 1.2930 mL | 3.2325 mL | |
| 30 mM | 0.1077 mL | 0.5387 mL | 1.0775 mL | 2.6937 mL | |
| 40 mM | 0.0808 mL | 0.4041 mL | 0.8081 mL | 2.0203 mL | |
| 50 mM | 0.0646 mL | 0.3232 mL | 0.6465 mL | 1.6162 mL | |
| 60 mM | 0.0539 mL | 0.2694 mL | 0.5387 mL | 1.3469 mL | |
| 80 mM | 0.0404 mL | 0.2020 mL | 0.4041 mL | 1.0102 mL | |
| 100 mM | 0.0323 mL | 0.1616 mL | 0.3232 mL | 0.8081 mL |
CGS 20625 Related Classifications
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