1-Hydroxypyrene-d9
Based on 1 Customer Validation
1-Hydroxypyrene-d9 is the deuterium labeled 1-Hydroxypyrene (HY-W014075). 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.64%
- CAS. Nr.: 132603-37-3
- Formel: C16HD9O
- Molecular Weight:227.31
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 132603-37-3
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Unlabeled CAS 5315-79-7
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Appearance Solid
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Molecular Weight 227.31
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Formel C16HD9O
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Color White to off-white
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SMILES
OC1=C2C3=C4C(C([2H])=C2[2H])=C([2H])C([2H])=C([2H])C4=C([2H])C([2H])=C3C([2H])=C1[2H]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (219.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Fernando Freitas, et al. Urinary 1-hydroxypyrene Is Associated With Oxidative Stress and Inflammatory Biomarkers in Acute Myocardial Infarction. Int J Environ Res Public Health [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3993 mL | 21.9964 mL | 43.9928 mL | 109.9820 mL |
| 5 mM | 0.8799 mL | 4.3993 mL | 8.7986 mL | 21.9964 mL | |
| 10 mM | 0.4399 mL | 2.1996 mL | 4.3993 mL | 10.9982 mL | |
| 15 mM | 0.2933 mL | 1.4664 mL | 2.9329 mL | 7.3321 mL | |
| 20 mM | 0.2200 mL | 1.0998 mL | 2.1996 mL | 5.4991 mL | |
| 25 mM | 0.1760 mL | 0.8799 mL | 1.7597 mL | 4.3993 mL | |
| 30 mM | 0.1466 mL | 0.7332 mL | 1.4664 mL | 3.6661 mL | |
| 40 mM | 0.1100 mL | 0.5499 mL | 1.0998 mL | 2.7495 mL | |
| 50 mM | 0.0880 mL | 0.4399 mL | 0.8799 mL | 2.1996 mL | |
| 60 mM | 0.0733 mL | 0.3666 mL | 0.7332 mL | 1.8330 mL | |
| 80 mM | 0.0550 mL | 0.2750 mL | 0.5499 mL | 1.3748 mL | |
| 100 mM | 0.0440 mL | 0.2200 mL | 0.4399 mL | 1.0998 mL |
1-Hydroxypyrene-d9 Related Classifications
HY-W014075S Related Classifications
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