A-74273
A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension.
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- CAS. Nr.: 130316-95-9
- Formel: C44H74N4O8
- Molecular Weight:787.08
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Chemical Information
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CAS. Nr. 130316-95-9
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Molecular Weight 787.08
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Formel C44H74N4O8
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SMILES
CCCC[C@H](O[C@H](C(N1CCC(OCOC)CC1)=O)CC2=CC=CC=C2)C(NC(C(O)C[C@H](C(NCCCN3CCOCC3)=O)C(C)C)CC4CCCCC4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Dayton, et al. Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors. Clinical chemistry 38.11 (1992): 2239-2243. [Content Brief]
[2]. Kleinert, et al. "Discovery of a well-absorbed, efficacious renin inhibitor, A-74273." Hypertension 20.6 (1992): 768-775. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
A-74273 Related Classifications
HY-129412 Related Classifications
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