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Art. -Nr.: HY-187316A

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Alkyne-PEG2000-CTP

Name: Alkyne-PEG2000-CTP
Brand: MedChemExpress
SKU: HY-187316A
Availability: PreOrder

(Synonyms: Alkyne-PEG2000-APWHLSSQYSRT)

Alkyne-PEG2000-CTP is a functionalized PEGylated lipid conjugate composed of three modular components: alkyne (propargyl/alkyne linker) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and CTP (cardiotropic targeting peptide) (HY-P4094) as the terminal targeting/functional ligand. Alkyne-PEG2000-CTP does not contain a lipid anchoring group but instead provides a terminal reactive site for post-assembly ligand or probe conjugation on PEGylated nanoparticles.

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Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Alkyne-PEG2000-CTP Chemical Structure

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Beschreibung

In Vitro

Alkyne-PEG2000-CTP is specifically designed for active targeting nanomedicine applications. It can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against brain endothelial cell receptors/CNS-specific transport mechanisms.
Composition and role of each component:
1. PEG2000 (polyethylene glycol, MW 2000): Hydrophilic polymer spacer arm that forms a steric corona around nanoparticles, reducing opsonization and reticuloendothelial system (RES) clearance, prolonging circulation half-life, and providing spatial separation between the lipid surface and targeting ligand.
2. CTP: Targeting ligand-can be reversibly linked (e.g., via enolase, thiol groups) to a carrier (e.g., miRNA), thereby enabling specific delivery to cardiomyocytes rather than all other organs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[Alkyne-PEG2000-CTP]
Synonyms

Alkyne-PEG2000-APWHLSSQYSRT
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.