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Art. -Nr.: HY-149089

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Antibacterial agent 138

Antibacterial agent 138 has excellent antibacterial activity to multi-drug resistant bacteria. Antibacterial agent 138 inhibits bacterial protein synthesis but bacterial cell walls.

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CAS. Nr.: 2971788-27-7
Formel: C₃₄H₅₂INO₄S
Molecular Weight:697.75

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antibacterial agent 138 Chemical Structure

CAS. Nr.: 2971788-27-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Antibacterial agent 138 has excellent antibacterial activity to multi-drug resistant bacteria. Antibacterial agent 138 inhibits bacterial protein synthesis but bacterial cell walls^[1].

In Vitro

Antibacterial agent 138 (compound e4) (0.063 μg/mL, 24 h) shows excellent inhibition against MRSA and MRSE^[1].
Antibacterial agent 138 has antimicrobial activity against multi-drug resistant bacteria, with MICs ( 0.063-32μg/mL) 16-64 times lower than that of Tiamulin^[1].
Antibacterial agent 138 (60 μg/mL, 24 h) shows no signs of cytotoxicity in HEPG2 and HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

S. aureus, MRSA, S. pneumonia, MRSE, B. subtilis, VRE, K. peneumoniae.
Concentration:

0-50 μg/mL approximately.
Incubation Time:

24 h
Result:

MICs: 0.063, 0.063, <0.031, 0.063, 4, 4, 2 μg/mL

In Vivo

Antibacterial agent 138 (compound e4) (2.5-40 mg/kg, i.p.) shows antibacterial activity in a mice model of systemic multi-drug resistant S. aureus infection ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice model of systemic multi-drug resistant S. aureus infection^[1]
Dosage:

2.5, 5, 10, 20, 40 mg/kg
Administration:

i.p.
Result:

Prolonged survival rate.
Reduced bacterial loads in the lungs and liver of infected mice.

Related Protocols :

Chemical Information

CAS. Nr. 2971788-27-7
Molecular Weight 697.75
Formel C₃₄H₅₂INO₄S
SMILES

C[C@@H]1[C@]23[C@](C(CC3)=O)([H])[C@]([C@@H](C[C@](C)([C@H]1O)C=C)OC(CSC4=CC=[N+](CCCCCCC)C=C4)=O)([C@@H](CC2)C)C.[I-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yi Y, et al. Novel pyridinium cationic pleuromutilin analogues overcoming bacterial multidrug resistance. Eur J Med Chem. 2023 May 5;251:115269. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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