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Art. -Nr.: HY-149367

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Anticancer agent 136

Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM; HY-15230), has an IC₅₀ of 3.38 μM for HDF and a K_d of 3.86 μM for Hsp90. Anticancer agent 136 is an apoptosis-inducing agent.

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CAS. Nr.: 3049419-74-8
Formel: C₄₀H₅₀N₆O₈
Molecular Weight:742.86

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 136 Chemical Structure

CAS. Nr.: 3049419-74-8

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
NHDF	IC₅₀	3.38 μM Compound: 22	Cytotoxicity against human HDF cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human HDF cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37210951]
PC-3	IC₅₀	1.11 μM Compound: 22	Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37210951]
SK-BR-3	IC₅₀	1.16 μM Compound: 22	Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37210951]
SK-OV-3	IC₅₀	1.08 μM Compound: 22	Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37210951]

Chemical Information

CAS. Nr. 3049419-74-8
Molecular Weight 742.86
Formel C₄₀H₅₀N₆O₈
SMILES

O=C1C(NCC2=CN(C/C=C/C3=CC=CC=C3)N=N2)=C4C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C4)=O)=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Natalia Skrzypczak, et al. Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity. Eur J Med Chem. 2023 Aug 5;256:115450. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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