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Art. -Nr.: HY-162560

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Antitumor agent-162

Antitumor agent-162 (compound 52a) is a potent and orally active antitumor agent. Antitumor agent-162 shows cytotoxicity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₆H₁₉Cl₂NO₄
Molecular Weight:480.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antitumor agent-162 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Antitumor agent-162 (compound 52a) is a potent and orally active antitumor agent. Antitumor agent-162 shows cytotoxicity^[1].

In Vitro

Antitumor agent-162 (compound 52a) (0-5000 nM) shows cytotoxicity with IC₅₀s of 63, 84 nM for Mut6, UTSW63 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic Parameters^[1].

	route	T_1/2 (h)	C_max (ng/mL)	T_max (h)	AUC_last (ng*min/mL)	CL	kp (AUCbrain/AUCplasma)
plasma	i.p. (10 mg/kg)	234	1303	30	289860	0.13	-
	i.v. (5 mg/kg)	189	12000	5	885630	0.14	-
	p.o. (20 mg/kg)	208	3404	30	1387613	0.14	-
brain	i.p. (10 mg/kg)	182	2526	90	720503	-	2.49
	i.v. (5 mg/kg)	294	3257	5	767638	-	0.87
	p.o. (20 mg/kg)	254	2381	90	1774789	-	1.28

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 480.34
Formel C₂₆H₁₉Cl₂NO₄
SMILES

ClC1=CC(Cl)=CC(C(COC2=CC=C(C=C2)N3C(C4C(C5C6CC6C57C=CC47)C3=O)=O)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang HY, et al. Discovery and Optimization of N-Arylated Tetracyclic Dicarboximides That Target Primary Glioma Stem-like Cells. J Med Chem. 2024 May 28. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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