Antitumor agent-36
Antitumor agent-36 possesses potent anti-proliferative and anti-metastasis activities. Antitumor agent-36 induces serious DNA damage and further leads to high expression of γ-H2AX and p53. Antitumor agent-36 promotes apoptosis of tumor cells through mitochondrial apoptotic pathway Bcl-2/Bax/caspase3. Antitumor agent-36 significantly improves immune response through restraining the expression of PD-L1 to increase CD3+ and CD8+ T infiltrating cells in tumor tissues.
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- CAS. Nr.: 3005986-81-9
- Formel: C32H32Cl2N2O6Pt
- Molecular Weight:806.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
apoptosis[1]
In Vitro
Antitumor agent-36 (compound 1) (24-76 hours) displays relatively lower activities after 24 h treatment, and the IC50 values decreases at 48 h, and the activities at 72 h are similar to that of 48 h[1].
Antitumor agent-36 (compound 1) (24 hours) induces significant apoptosis of tumor cells.[1].
Antitumor agent-36 (compound 1) (24 hours) are effective in modulating the expression of apoptotic proteins in tumor cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:murine tumor cell line 4T1 and human tumor cell line A549
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Concentration:5 and 10 μM
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Incubation Time:24 hours
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Result:Exhibited effective apoptosis induction of both A549 and 4T1 cells after 24 h treatment.
Chemical Information
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CAS. Nr. 3005986-81-9
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Molecular Weight 806.60
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Formel C32H32Cl2N2O6Pt
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SMILES
O=C(C1=CC=CC(C(C(O[Pt](Cl)([NH3])(Cl)([NH3])OC(C(C2=CC=CC(C(C3=CC=CC=C3)=O)=C2)C)=O)=O)C)=C1)C4=CC=CC=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antitumor agent-36 Related Classifications
HY-145288 Related Classifications
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