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Art. -Nr.: HY-189133

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ARN24092

ARN24092 is a selective NKCC1 inhibitor. ARN24092 can be used for research on Down syndrome.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2746327-43-3
Formel: C₁₇H₂₅F₃N₂O₅S
Molecular Weight:426.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

ARN24092 Chemical Structure

CAS. Nr.: 2746327-43-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ARN24092 is a selective NKCC1 inhibitor. ARN24092 can be used for research on Down syndrome^[1].

IC₅₀ & Target

^[1]

NKCC1

In Vitro

ARN24092 (compound 40) (10-100 μM; 15 min) significantly inhibits NKCC1 in cultured hippocampal neurons, with an inhibition rate of 13.9% at 10 μM and 51.9% at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ARN24092 (compound 40) (0.6 mg/kg; intraperitoneal injection; daily; approximately 21 days) improved cognitive impairment across four different behavioral tasks in the Ts65Dn mouse model of Down syndrome without producing any diuretic effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ts65Dn (C57BL/6JEi × C3H/HeSnJ F1 background, adult males, 2-4 months old for diuresis; 8-16 weeks old for behavioral testing)^[1]
Dosage:

0.6 mg/kg
Administration:

i.p.; daily; ~21 days
Result:

Did not induce significant diuresis in WT or Ts65Dn mice.
Fully restored short-term working memory in Ts65Dn mice in T-maze.
Completely rescued poor novel-discrimination ability in Ts65Dn mice in NOR task.
Completely restored associative memory in Ts65Dn mice in CFC test.
Rescued hyperactivity in Ts65Dn mice in open-field test.
Did not affect general health or body weight after 3 weeks of daily administration.

Chemical Information

CAS. Nr. 2746327-43-3
Molecular Weight 426.45
Formel C₁₇H₂₅F₃N₂O₅S
SMILES

O=C(C1=C(O)C=C(NCCCCCCCC(F)(F)F)C(S(=O)(N(C)C)=O)=C1)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Borgogno M, et al. Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome. J Med Chem. 2021 Jul 22;64(14):10203-10229.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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