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Art. -Nr.: HY-P992094

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Capromab

Capromab is an anti-human PSMA-targeting monoclonal antibody. Capromab binds specifically to the intracellular domain of PSMA, does not undergo internalization after binding, and targets necrotic cells with disrupted membranes. Capromab can be used for the research of prostate cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 151763-64-3

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Capromab Chemical Structure

CAS. Nr.: 151763-64-3

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Preis

Verfügbarkeit

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Mouse IgG1 kappa

Recommend Isotype Controls

Mouse IgG1 kappa, Isotype Control

Species Reactivity

Human

In Vitro

Capromab (Radiolabeled) (10 nM; 2 h) binds specifically to permeabilized PSMA-expressing LNCaP cells, with minimal unspecific binding to PSMA-negative PC3 cell membranes^[1].
Capromab (¹²⁵I-capromab) (10 nM) retains an immunoreactive fraction of 83 ± 2% when binding to PSMA-expressing LNCaP cell membranes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Capromab (¹²⁵I-capromab) (3 μg per animal; i.v. (tail vein); single dose) demonstrates specific targeting of PSMA-positive prostate cancer xenografts, as shown by significantly lower uptake in PSMA-negative PC3 xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nu/nu mice (male; subcutaneous PC3 xenograft, 3 weeks post-injection)^[1]
Dosage:

3 μg total antibody per animal
Administration:

i.v. (tail vein); single dose
Result:

Showed significantly lower (p < 0.01) tumor uptake in PSMA-negative PC3 xenografts compared to PSMA-positive LNCaP xenografts, with uptake levels comparable to muscle tissue.

Gene ID

2346 [NCBI]

Accession

Q04609

Target

FOLH1/PSMA

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Anwendung

ELISA, FACS, Functional assay

Chemical Information

CAS. Nr. 151763-64-3
SMILES

[Capromab]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Tolmachev V, et al. Development of a 124I-labeled version of the anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer: Aspects of labeling chemistry and biodistribution. Int J Oncol. 2014;44(6):1998-2008. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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