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Art. -Nr.: HY-130762

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Cinnamic acid sodium

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Cinnamic acid sodium is a orally active naturally occurring aromatic fatty acid of low toxicity. Cinnamic acid sodium shows neuroprotective and anti-inflammatory effects.

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CAS. Nr.: 538-42-1
Formel: C₉H₇NaO₂
Molecular Weight:170.14

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Cinnamic acid sodium Chemical Structure

CAS. Nr.: 538-42-1

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- In Vitro
- In Vivo
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Publications (3)
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Biologische Aktivität

Beschreibung

Cinnamic acid sodium is a orally active naturally occurring aromatic fatty acid of low toxicity. Cinnamic acid sodium shows neuroprotective and anti-inflammatory effects^[1]^[2]^[3].

In Vitro

Cinnamic acid sodium (0.05, 0.4, 3.2 mM; 6, 12, 24 h) induces apoptosis in HT-144 cells in 3.2 mM at 24 h^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[3]

Cell Line:

NGM, HT-144 cells
Concentration:

0.05, 0.4, 3.2 mM
Incubation Time:

6, 12, 24 h
Result:

Induced apoptosis in HT-144 cells in 3.2 mM at 24 h, no effect apoptosis in NGM cells.

In Vivo

Cinnamic acid sodium (100 mg/kg; gavage) activates PPARα to protect the loss of dopaminergic neurons, restore striatal fibers and neurotransmitters, and improve the behavioral functions in MPTP-intoxicated mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-8 weeks, C57BL/6 mice (18 mg/kg MPTP-HCl, i.p.; at 2-h intervals for 4 times)^[1]
Dosage:

100 mg/kg
Administration:

Gavage; starting from 3 h after the last injection of MPTP
Result:

Protected nigral TH levels, protected striatal innervation and neurotransmitters, restored locomotor deficit, increased the activation of Peroxisome Proliferator-Activated Receptor alpha (PPARα) in primary mouse astrocytes, protected striatal TH via PPARα.

Chemical Information

CAS. Nr. 538-42-1
Molecular Weight 170.14
Formel C₉H₇NaO₂
SMILES

O=C(O[Na])/C=C/C1=CC=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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J Neurosci

Pharmacological and Genetic Approaches to Downregulate FIS1 Mitigate Neuropathic Pain. [Abstract]

2025 Aug 27;45(35):e0523252025. PMID: 40769725
Res Sq

2025 Feb 05.
Res Sq

2025 Jan 31.

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Prorok T, et al. Cinnamic Acid Protects the Nigrostriatum in a Mouse Model of Parkinson's Disease via Peroxisome Proliferator-Activated Receptorα. Neurochem Res. 2019 Apr;44(4):751-762. [Content Brief]

[2]. MA Hussein, et al. Evaluation of Anti-inflammatory Effects of Cinnamic Acid Against Dextran Sodium Sulfate-Induced Ulcerative Colitis in Male Mice. Iraqi J Pharm Sci, 2023, 32(2).

[3]. Niero EL, et al. Cinnamic acid induces apoptotic cell death and cytoskeleton disruption in human melanoma cells. J Exp Clin Cancer Res. 2013 May 23;32(1):31. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Cinnamic acid sodium

3 Cited Publications

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Cinnamic acid sodium

Publications Citing Use of MedChemExpress (MCE) Cinnamic acid sodium

Biologische Aktivität

Chemical Information

Publications (3)

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Cinnamic acid sodium Related Classifications

HY-130762 Related Classifications