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Art. -Nr.: HY-157412

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CRM1-IN-3

CRM1-IN-3 (B28) is a noncovalent CRM1 inhibitor. CRM1-IN-3 can be used for the research of protein localization and tumor.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1114628-25-9
Formel: C₂₆H₂₆ClN₃O₃
Molecular Weight:463.96

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CRM1-IN-3 Chemical Structure

CAS. Nr.: 1114628-25-9

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

CRM1-IN-3 (B28) is a noncovalent CRM1 inhibitor. CRM1-IN-3 can be used for the research of protein localization and tumor^[1].

Chemical Information

CAS. Nr. 1114628-25-9
Molecular Weight 463.96
Formel C₂₆H₂₆ClN₃O₃
SMILES

O=C(NC1=CC(C(O)=O)=CC=C1N2CCN(CC2)C3=CC(C)=CC=C3C)C4=CC=C(C=C4)Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology Molecular Biology

Antibody-based immunofluorescence/immunocytochemistry staining
Antibody-based immunofluorescence/immunocytochemistry detects the cellular or subcellular localization of a target antigen by binding a primary antibody to the target and detecting that antibody directly with a fluorophore-conjugated primary antibody or indirectly with a fluorophore-conjugated secondary antibody. Indirect immunofluorescence can amplify signal because multiple secondary antibodies can bind one primary antibody. The assay readout is fluorescence intensity and localization measured by fluorescence or confocal microscopy, and the result reflects antigen distribution only when the antibody has been validated for the target, sample type, fixation condition, and imaging workflow. Antibody specificity must not be assumed from catalog information alone, and appropriate validation or control experiments are required for serious interpretation.
Immunocytochemistry/Immunofluorescence

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li C, et al. Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. J Med Chem. 2023 Dec 18. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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