Cytochalasin J
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC50 of 1.5 μM.
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- CAS. Nr.: 53760-20-6
- Formel: C28H37NO4
- Molecular Weight:451.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μM
Compound: 17
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Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay
Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay
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[PMID: 35473314] |
| HepG2 | IC50 |
>50 μM
Compound: 17
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Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
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[PMID: 35473314] |
| MDA-MB-231 | IC50 |
31 μM
Compound: 17
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Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
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[PMID: 35473314] |
| MDA-MB-435 | IC50 |
4.9 μM
Compound: 17
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Cytotoxicity against human MDA-MB-435 cells measured after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells measured after 72 hrs by MTT assay
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[PMID: 35473314] |
| SNB-19 | IC50 |
6.8 μM
Compound: 17
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Cytotoxicity against human SNB-19 cells measured after 72 hrs by MTT assay
Cytotoxicity against human SNB-19 cells measured after 72 hrs by MTT assay
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[PMID: 35473314] |
| Vero | IC50 |
>50 μM
Compound: 17
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Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay
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[PMID: 35473314] |
Chemical Information
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CAS. Nr. 53760-20-6
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Molecular Weight 451.60
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Formel C28H37NO4
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SMILES
O=C([C@@]12[C@](/C=C/C[C@H](C)C[C@@](C)(O)/C=C/[C@H]2O)([H])[C@@H]3O)N[C@@H](CC4=CC=CC=C4)[C@]1([H])[C@H](C)C3=C
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Structure Classification
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Initial Source
Endothia gyrosa IFB-E023
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Xu S, et al., Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa. Chem Biodivers. 2009 May;6(5):739-45. [Content Brief]
[2]. Wrench GA, et al., Cytochalasin J treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in PtK1 cells. Cell Motil Cytoskeleton. 1997;36(2):112-24. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cytochalasin J Related Classifications
HY-126556 Related Classifications
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