(E)-4-Hydroxycrotonic acid
Based on 1 Customer Validation
(E)-4-Hydroxycrotonic acid (trans-4-Hydroxycrotonic acid) is a semirigid linear analog of γ-Hydroxybutyric acid. (E)-4-Hydroxycrotonic acid can be present in the mammalian central nervous system. (E)-4-Hydroxycrotonic acid binds to high-affinity γ-Hydroxybutyric acid binding sites and displaces radioligands.
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- Reinheit : 98.0%
- CAS. Nr.: 24587-49-3
- Formel: C4H6O3
- Molecular Weight:102.09
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[2]|
Human Endogenous Metabolite |
In Vitro
(E)-4-Hydroxycrotonic acid (up to 1000 μM; 1 h) binds the high-affinity binding site in rat brain cortical synaptosomal membranes with a Ki of 1.1 μM in the [3H]NCS-382 displacement assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 24587-49-3
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Appearance Solid
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Molecular Weight 102.09
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Formel C4H6O3
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Color Light yellow to yellow
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SMILES
O=C(O)/C=C/CO
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Synonyms
trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 175 mg/mL (1714.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (453 KB)
- English - EN (453 KB)
- Français - FR (453 KB)
- Deutsch - DE (453 KB)
- Norwegian - NO (453 KB)
- Español - ES (453 KB)
- Swedish - SV (453 KB)
- Italian - IT (453 KB)
- Korean - KR (453 KB)
- Portuguese - PT (453 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Krall J, et al. Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs. Journal of medicinal chemistry. 2017 Nov 09;60(21):9022-9039. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 9.7953 mL | 48.9764 mL | 97.9528 mL | 244.8820 mL |
| 5 mM | 1.9591 mL | 9.7953 mL | 19.5906 mL | 48.9764 mL | |
| 10 mM | 0.9795 mL | 4.8976 mL | 9.7953 mL | 24.4882 mL | |
| 15 mM | 0.6530 mL | 3.2651 mL | 6.5302 mL | 16.3255 mL | |
| 20 mM | 0.4898 mL | 2.4488 mL | 4.8976 mL | 12.2441 mL | |
| 25 mM | 0.3918 mL | 1.9591 mL | 3.9181 mL | 9.7953 mL | |
| 30 mM | 0.3265 mL | 1.6325 mL | 3.2651 mL | 8.1627 mL | |
| 40 mM | 0.2449 mL | 1.2244 mL | 2.4488 mL | 6.1220 mL | |
| 50 mM | 0.1959 mL | 0.9795 mL | 1.9591 mL | 4.8976 mL | |
| 60 mM | 0.1633 mL | 0.8163 mL | 1.6325 mL | 4.0814 mL | |
| 80 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0610 mL | |
| 100 mM | 0.0980 mL | 0.4898 mL | 0.9795 mL | 2.4488 mL |
(E)-4-Hydroxycrotonic acid Related Classifications
HY-100982 Related Classifications
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Keywords
- (E)-4-Hydroxycrotonic acid
- 24587-49-3
- trans-4-Hydroxycrotonic acid
- trans-γ-Hydroxycrotonic acid
- T‐HCA
- Drug Derivative
- Endogenous Metabolite
- GHB binding site
- cortical synaptosomal membranes
- high-affinity binding site
- human brain
- human renal tissue
- mammalian central nervous system
- metabolism enzymes
- radioligand
- rat brain
- uptake systems
- Inhibitor
- inhibitor
- inhibit