GalNAc-L96
Based on 1 Customer Validation
GalNAc-L96 is a conjugate of GalNAc and its ligand L96. When conjugated with the A-rich HCV sequence (H12), GalNAc-L96 binds potently to ASGPR, with a Ki value of 10.4 nM. GalNAc-L96 promotes siRNA delivery to hepatocytes.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 97.0%
- CAS. Nr.: 1159408-62-4
- Formel: C127H194N12O45
- Molecular Weight:2608.95
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
When conjugated to an A-rich HCV sequence (H12), GalNAc-L96 binds potently to ASGPR in primary mouse hepatocytes, with a Ki value of 10.4 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Humanized PCSK9 mice[1]
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Dosage:6 mg/kg
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Administration:s.c.; single dose
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Result:Reduced serum PCSK9 protein levels to ~10.2% of baseline at day 14 post-dose.
Reduced hepatic PCSK9 mRNA levels to ~19.9% of baseline at day 14 post-dose.
Chemical Information
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CAS. Nr. 1159408-62-4
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Appearance Solid
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Molecular Weight 2608.95
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Formel C127H194N12O45
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Color Off-white to light yellow
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SMILES
O=C(CCCCCCCCCCC(N1[C@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C[C@@H](OC(CCC(O)=O)=O)C1)=O)NC(COCCC(NCCCNC(CCCCO[C@H]5[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O5)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]6[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O6)=O)=O)COCCC(NCCCNC(CCCCO[C@H]7[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O7)=O)=O.CCN(CC)CC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 125 mg/mL (47.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Pradeep SP, et al. Enhanced liver-targeted delivery with ribofuranose-based GalNAc conjugates. Mol Ther Nucleic Acids. 2026;37(1):102871. Published 2026 Mar 4. [Content Brief]
[2]. Clua A, et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules. 2022;27(12):3944. Published 2022 Jun 20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.3833 mL | 1.9165 mL | 3.8330 mL | 9.5824 mL |
| 5 mM | 0.0767 mL | 0.3833 mL | 0.7666 mL | 1.9165 mL | |
| 10 mM | 0.0383 mL | 0.1916 mL | 0.3833 mL | 0.9582 mL | |
| 15 mM | 0.0256 mL | 0.1278 mL | 0.2555 mL | 0.6388 mL | |
| 20 mM | 0.0192 mL | 0.0958 mL | 0.1916 mL | 0.4791 mL | |
| 25 mM | 0.0153 mL | 0.0767 mL | 0.1533 mL | 0.3833 mL | |
| 30 mM | 0.0128 mL | 0.0639 mL | 0.1278 mL | 0.3194 mL | |
| 40 mM | 0.0096 mL | 0.0479 mL | 0.0958 mL | 0.2396 mL |
GalNAc-L96 Related Classifications
HY-147012 Related Classifications
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